Paper Info
Title
Regional brain atrophy in children with multiple sclerosis.
Abstract
We used cross-sectional tensor-based morphometry to visualize reduced volume in the whole brains of pediatric patients with multiple sclerosis, relative to healthy controls. As a marker of local volume difference, we used the Jacobian determinant of the deformation field that maps each subject to a standard space. To properly assess abnormal differences in volume in this age group, it is necessary to account for the normal, age-related differences in brain volume. This was accomplished by computing normalized z-score Jacobian determinant values at each voxel to represent the local volume difference (in standard deviations) between an individual subject and an age- and sex-matched healthy normal population. Compared with healthy controls, pediatric patients with multiple sclerosis exhibited significantly reduced volumes within the thalamus and the splenium of the corpus callosum and significant expansions in the ventricles. While T2-weighted lesion volume was correlated with reduced splenium volume, no correlation was found between T2-weighted lesion volume and reduced thalamic volume. Reduced volumes of the optic pathways, including that of the optic tracts and optic radiations, correlated with disease duration. Our results suggest that focal inflammatory lesions may play an important role in tract degeneration, including transsynaptic degeneration.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2011.03.025
NeuroImage
Keywords
Field
DocType
cross section,age groups,standard deviation
Developmental psychology,Population,Lesion,Multiple sclerosis,Psychology,Optic tract,Brain size,Atrophy,Corpus callosum,Pathology,Splenium
Journal
Volume
Issue
ISSN
58
2
1053-8119
Citations 
PageRank 
References 
3
0.43
7
Authors
8
Name
Order
Citations
PageRank
Berengere Aubert-Broche116614.12
Vladimir Fonov247820.32
R Ghassemi330.43
Sridar Narayanan416611.38
Douglas L Arnold534031.44
B Banwell630.43
John G. Sled7688191.06
D. Louis Collins83915403.90