Paper Info
Title
Transcompel((R)): A Database On Composite Regulatory Elements In Eukaryotic Genes
Abstract
Originating from COMPEL, the TRANSCompel((R)) database emphasizes the key role of specific interactions between transcription factors binding to their target sites providing specific features of gene regulation in a particular cellular content. Composite regulatory elements contain two closely situated binding sites for distinct transcription factors and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor-DNA and factor-factor interactions contribute to the function of composite elements (CEs). Information about the structure of known CEs and specific gene regulation achieved through such CEs appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. Each database entry corresponds to an individual CE within a particular gene and contains information about two binding sites, two corresponding transcription factors and experiments confirming cooperative action between transcription factors. The COMPEL database, equipped with the search and browse tools, is available at http://www.gene-regulation.com/pub/databases.html#transcompel. Moreover, we have developed the program CATCH(TM) for searching potential CEs in DNA sequences. It is freely available as CompelPatternSearch at http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html.
Year
DOI
Venue
2002
10.1093/nar/30.1.332
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
transcription factors,binding sites,internet,systems integration
Transcriptional regulation,Gene,Binding site,Biology,DNA,Regulation of gene expression,DNA sequencing,Genetics,Molecular biology,Transcription factor,Database
Journal
Volume
Issue
ISSN
30
1
0305-1048
Citations 
PageRank 
References 
33
5.12
4
Authors
5
Name
Order
Citations
PageRank
O V Kel-Margoulis11088143.05
A Kel21201166.83
I Reuter31177159.90
Igor Deineko4379.96
Edgar Wingender51975322.27