Paper Info
Title
Web Applications Supporting the Development of Models of Chagas' Disease for Left Ventricular Myocytes of Adult Rats
Abstract
Chagas' Disease is an endemic infection in many areas of South and Central America that may cause a fatal type of myocarditis. In the acute phase of the disease, ventricular extrasystoles and tachycardia have been reported. Experiments with cardiac myocytes in the acute stage of Chagas' Disease have suggested a depression of Ito, the Ca2 +-independent K+Transient Outward current. In this work we use computational models of left ventricular myocytes of adult rats to qualify the effects of Itoreduction that appear during the acute phase of Chagas' Disease. The simulations are carried out by Web applications based on the CellML language, a recently emerged international standard for the description of biological models. The computational framework supports the development of mathematical models, simulations and visualization of the results. Our preliminary simulation results suggest that the reduction of Itodensity elicits modifications of electrophysiological mechanisms that are strongly related to the phenomena of arrhythmia.
Year
DOI
Venue
2008
10.1007/978-3-540-69389-5_15
ICCS (3)
Keywords
Field
DocType
computational framework,ventricular extrasystole,itodensity elicits modification,cardiac myocytes,left ventricular myocytes,computational model,acute stage,web applications,cellml language,acute phase,central america,adult rats,computer model,web based simulation,chagas disease,internal standard,mathematical model
Tachycardia,CellML,Myocyte,Disease,Myocarditis,Internal medicine,Computer science,Cardiology,Chagas disease,Ventricular extrasystoles,Distributed computing,Cardiac transient outward potassium current
Conference
Volume
ISSN
Citations 
5103
0302-9743
0
PageRank 
References 
Authors
0.34
4
4
Name
Order
Citations
PageRank
Caroline Mendonça Costa1104.59
Ricardo Silva Campos2195.70
Fernando Otaviano Campos3316.99
weber dos santos r419944.90