Paper Info
Title
Investigation of attenuation correction for small-animal single photon emission computed tomography.
Abstract
The quantitative accuracy of SPECT is limited by photon attenuation and scatter effect when photons interact with atoms. In this study, we developed a new attenuation correction (AC) method, CT-based mean attenuation correction (CTMAC) method, and compared it with various methods that were often used currently to assess the AC phenomenon by using the small-animal SPECT/CT data that were acquired from various physical phantoms and a rat. The physical phantoms and an SD rat, which were injected with Tc-99m, were scanned by a parallel-hole small-animal SPECT, and then they were imaged by the 80 kVp micro-CT. Scatter was estimated and corrected by the triple-energy window (TEW) method. Absolute quantification was derived from a known activity point source scan. In the physical-phantom studies, we compared the images with original, scatter correction (SC) only, and the scatter-corrected images with AC performed by using Chang's method, CT-based attenuation correction (CTAC), CT-based iterative attenuation compensation during reconstruction (CTIACR), and the CTMAC. From the correction results, we find out that the errors of the previous six configurations are mostly quite similar. The CTMAC needs the shortest correction time while obtaining good AC results.
Year
DOI
Venue
2013
10.1155/2013/430276
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Field
DocType
Volume
Single-photon emission computed tomography,Photon,X-ray microtomography,Optics,Photon attenuation,Point source,Correction for attenuation,Attenuation,Scatter correction,Physics
Journal
2013
ISSN
Citations 
PageRank 
1748-670X
0
0.34
References 
Authors
1
2
Name
Order
Citations
PageRank
Hsin-Hui Lee100.68
Jyh-Cheng Chen283.60