Title
Exploring Patient Risk Groups with Incomplete Knowledge
Abstract
Patient risk stratification, which aims to stratify a patient cohort into a set of homogeneous groups according to some risk evaluation criteria, is an important task in modern medical informatics. Good risk stratification is the key to good personalized care plan design and delivery. The typical procedure for risk stratification is to first identify a set of risk-relevant medical features (also called risk factors), and then construct a predictive model to estimate the risk scores for individual patients. However, due to the heterogeneity of patients' clinical conditions, the risk factors and their importance vary across different patient groups. Therefore a better approach is to first segment the patient cohort into a set of homogeneous groups with consistent clinical conditions, namely risk groups, and then develop group-specific risk prediction models. In this paper, we propose RISGAL (RISk Group Analysis), a novel semi-supervised learning framework for patient risk group exploration. Our method segments a patient similarity graph into a set of risk groups such that some risk groups are in alignment with (incomplete) prior knowledge from the domain experts while the remaining groups reveal new knowledge from the data. Our method is validated on public benchmark datasets as well as a real electronic medical record database to identify risk groups from a set of potential Congestive Heart Failure (CHF) patients.
Year
DOI
Venue
2013
10.1109/ICDM.2013.129
ICDM
Keywords
Field
DocType
patient clinical condition heterogeneity,congestive heart failure patients,electronic medical records,risk group analysis,risk-relevant medical features,patient risk stratification,electronic health records,learning (artificial intelligence),domain experts,group-specific risk prediction models,risk factors,risk analysis,electronic medical record database,incomplete knowledge,risgal,chf,semisupervised learning framework,patient care,patient cohort,personalized care plan design,risk scores,medical informatics,risk evaluation criteria,graph theory,homogeneous groups,patient risk group exploration,medical computing,semi-supervised learning,patient similarity graph,learning artificial intelligence
Data mining,Semi-supervised learning,Risk analysis (business),Computer science,Medical record,Group analysis,Predictive modelling,Cluster analysis,Health informatics,Cohort
Conference
ISSN
Citations 
PageRank 
1550-4786
3
0.40
References 
Authors
8
5
Name
Order
Citations
PageRank
Xiang Wang135627.72
Fei Wang227219.41
Jun Wang349414.79
Buyue Qian422021.63
Jianying Hu547835.52