Paper Info
Title
Fusion of optical imaging and MRI for the evaluation and adjustment of macroscopic models of cardiac electrophysiology: a feasibility study.
Abstract
The aim of this work was to demonstrate the correspondence between a macroscopic 3D computer model of electrophysiology (i.e., the Aliev–Panfilov model) parametrized with MR data and experimental characterization of action potential propagation in large porcine hearts, ex vivo, using optical methods (based on voltage-sensitive fluorescence). A secondary goal was to use one of these studies to demonstrate an optimized method for regional adjustment of critical model parameters (i.e., adjustment of the local conductivity from the isochronal maps obtained via optical images). There was good agreement between model behaviour and experiment using fusion of optical and MR data, and model parameters from previous work in the literature. Specifically, qualitative comparison between computed and measured activation maps gave good results. Adjustment of the conductivity parameter within 26 regions fitting data from the current experiments in one heart reduced absolute error in local depolarization times by a factor of 3 (i.e. from 30 to 10ms).
Year
DOI
Venue
2009
10.1016/j.media.2008.07.002
Medical Image Analysis
Keywords
Field
DocType
Computer modelling,Electrophysiology,Optical imaging,MRI
Computer vision,Parametrization,Computer science,Cardiac electrophysiology,Fusion,Artificial intelligence,Optical imaging,Approximation error
Journal
Volume
Issue
ISSN
13
2
1361-8415
Citations 
PageRank 
References 
14
1.91
5
Authors
10
Name
Order
Citations
PageRank
Mihaela Pop18719.46
Maxime Sermesant21111122.97
D Lepiller3202.67
Michael V Truong4202.72
E. Mcveigh533540.50
Eugene Crystal6286.46
Alexander Dick7345.00
Herve Delingette81300136.45
Nicholas Ayache9108041654.36
Graham A. Wright1012325.09