Name
Title | ||
|---|---|---|
A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the Xenopus laevis: the localized transient heat block. |
Abstract | ||
|---|---|---|
The electrical behavior of the Xenopus laevis nerve fibers was studied when combined electrical (cuff electrodes) and optical (infrared laser, low power sub-5 mW) stimulations are applied. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric-field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1109/TBME.2012.2194146 | IEEE Trans. Biomed. Engineering |
Keywords | Field | DocType |
electric-field distribution,cellular biophysics,medical disorders,bioelectric potentials,laser irradiation,finite-element model,neurophysiology,electrical properties,transient block,neural engineering,neuron model,neuron,localized transient heat block,physiological models,electrical stimulation,heat block,finite element analysis,myelinated nerve fiber,thermoelectric extracellular stimulation,nerve action potentials,nerve tissue,sciatic nerve,thermoelectricity,laser applications in medicine,biological tissues,stimulation current profile,extracellular stimulation,optical stimulation,xenopus laevis nerve fibers,neural nets,finite-element method,action potential,optical fibers,action potentials,fiber optic,finite element model,fiber lasers,mathematical model,cathodes,electric field,extracellular,finite element method,infrared,computer simulation,fiber laser | Biomedical engineering,Biological neuron model,Neural Conduction,Computer science,Xenopus,Nerve block,Thermoelectric effect,Sciatic nerve,Stimulation,Myelinated nerve fiber | Journal |
Volume | Issue | ISSN |
59 | 6 | 1558-2531 |
Citations | PageRank | References |
3 | 0.61 | 2 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zongxia Mou | 1 | 3 | 0.95 |
| I. F. Triantis | 2 | 56 | 13.99 |
| Virginia M Woods | 3 | 3 | 0.61 |
| Christofer Toumazou | 4 | 265 | 59.06 |
| Konstantin Nikolic | 5 | 26 | 8.09 |