Paper Info
Title
The National Microbial Pathogen Database Resource (Nmpdr): A Genomics Platform Based On Subsystem Annotation
Abstract
The National Microbial Pathogen Data Resource (NMPDR) (http://www.nmpdr.org) is a National Institute of Allergy and Infections Disease (NIAID)-funded Bioinformatics Resource Center that supports research in selected Category B pathogens. NMPDR contains the complete genomes of similar to 50 strains of pathogenic bacteria that are the focus of our curators, as well as > 400 other genomes that provide a broad context for comparative analysis across the three phylogenetic Domains. NMPDR integrates complete, public genomes with expertly curated biological subsystems to provide the most consistent genome annotations. Subsystems are sets of functional roles related by a biologically meaningful organizing principle, which are built over large collections of genomes; they provide researchers with consistent functional assignments in a biologically structured context. Investigators can browse subsystems and reactions to develop accurate reconstructions of the metabolic networks of any sequenced organism. NMPDR provides a comprehensive bioinformatics platform, with tools and viewers for genome analysis. Results of precomputed gene clustering analyses can be retrieved in tabular or graphic format with one-click tools. NMPDR tools include Signature Genes, which finds the set of genes in common or that differentiates two groups of organisms. Essentiality data collated from genome-wide studies have been curated. Drug target identification and high-throughput, in silico, compound screening are in development.
Year
DOI
Venue
2007
10.1093/nar/gkl947
NUCLEIC ACIDS RESEARCH
Keywords
DocType
Volume
bacteria,internet,genomics
Journal
35
Issue
ISSN
Citations 
Database-Issue
0305-1048
16
PageRank 
References 
Authors
3.03
12
29
Name
Order
Citations
PageRank
Leslie Klis Mcneil1313.38
C Reich2163.37
Ramy K. Aziz3685.22
Daniela Bartels4286.60
Matthew Cohoon5163.37
Terry Disz640728.23
Robert Edwards718618.91
Svetlana Gerdes8706.19
Kaitlyn Hwang9163.03
M Kubal1018916.69
Gohar Rem Margaryan11163.03
Folker Meyer1248451.83
William Mihalo13163.03
Gary J. Olsen1430195.93
Robert Olson1550838.89
Andrei L Osterman169812.52
D Paarmann1718916.69
T Paczian1822121.05
Bruce Parrello195910.25
Gordon D Pusch2021732.32
Dmitry A. Rodionov21336.59
Xinghua Shi22163.03
Olga Vasieva23334.95
Veronika Vonstein2414510.65
Olga Zagnitko25193.47
Fangfang Xia26818.78
Jenifer Zinner27163.03
Ross A. Overbeek28760234.40
Rick L. Stevens291327135.40