Name
Title | ||
|---|---|---|
A 3D MRI-based cardiac computer model to study arrhythmia and its in-vivo experimental validation |
Abstract | ||
|---|---|---|
The aim of this work was to develop a simple and fast 3D MRI-based computer model of arrhythmia inducibility in porcine hearts with chronic infarct scar, and to further validate it using electrophysiology (EP) measures obtained in-vivo. The heart model was built from MRI scans (with voxel size smaller than 1mm3) and had fiber directions extracted from diffusion tensor DT-MRI. We used a macroscopic model that calculates the propagation of action potential (AP) after application of a train of stimuli, with location and timing replicating precisely the stimulation protocol used in the in-vivo EP study. Simulation results were performed for two infarct hearts: one with noninducible and the other with inducible ventricular tachycardia (VT), successfully predicting the study outcome like in the in-vivo cases; for the inducible heart, the average predicted VT cycle length was 273ms, compared to a recorded VT of approximately 250ms. We also generated synthetic fibers for each heart and found the associated helix angle whose transmural variation (in healthy zones) from endo- to epicardium gave the smallest difference (i.e., approx. 41°) when compared to the helix angle corresponding to fibers from DW-MRI. Mean differences between activation times computed using DT-MRI fibers and using synthetic fibers for the two hearts were 6 ms and 11 ms, respectively. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/978-3-642-21028-0_25 | FIMH |
Keywords | Field | DocType |
mri-based cardiac computer model,mri-based computer model,in-vivo experimental validation,macroscopic model,vt cycle length,heart model,in-vivo ep study,inducible heart,in-vivo case,porcine heart,synthetic fiber,infarct heart,action potential,diffusion tensor,computer model | Biomedical engineering,Voxel,Helix angle,Diffusion MRI,Fiber,Synthetic fiber,Simulation,In vivo,Ventricular tachycardia,Materials science,Electrophysiology | Conference |
Volume | ISSN | Citations |
6666 | 0302-9743 | 1 |
PageRank | References | Authors |
0.43 | 4 | 11 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Mihaela Pop | 1 | 87 | 19.46 |
| Maxime Sermesant | 2 | 1111 | 122.97 |
| Jean-Marc Peyrat | 3 | 375 | 27.30 |
| Eugene Crystal | 4 | 28 | 6.46 |
| Sudip Ghate | 5 | 9 | 3.12 |
| Tommaso Mansi | 6 | 454 | 45.94 |
| Ilan Lashevsky | 7 | 1 | 1.11 |
| Beiping Qiang | 8 | 1 | 0.77 |
| E. Mcveigh | 9 | 335 | 40.50 |
| Nicholas Ayache | 10 | 10804 | 1654.36 |
| Graham A. Wright | 11 | 123 | 25.09 |