Name
Title | ||
|---|---|---|
Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values. |
Abstract | ||
|---|---|---|
comb-p is a command-line tool and a python library that manipulates BED files of possibly irregularly spaced P-values and (1) calculates auto-correlation, (2) combines adjacent P-values, (3) performs false discovery adjustment, (4) finds regions of enrichment (i.e. series of adjacent low P-values) and (5) assigns significance to those regions. In addition, tools are provided for visualization and assessment. We provide validation and example uses on bisulfite-seq with P-values from Fisher's exact test, tiled methylation probes using a linear model and Dam-ID for chromatin binding using moderated t-statistics. Because the library accepts input in a simple, standardized format and is unaffected by the origin of the P-values, it can be used for a wide variety of applications. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1093/bioinformatics/bts545 | BIOINFORMATICS |
Field | DocType | Volume |
Chromatin binding,Linear model,Computer science,Visualization,Software,Bioinformatics,Python (programming language) | Journal | 28 |
Issue | ISSN | Citations |
22 | 1367-4803 | 8 |
PageRank | References | Authors |
2.01 | 1 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Brent S. Pedersen | 1 | 53 | 7.42 |
| David A. Schwartz | 2 | 14 | 4.35 |
| Ivana V. Yang | 3 | 9 | 2.39 |
| Katherina J. Kechris | 4 | 9 | 2.39 |