Title
Computational models of signalling networks for non-linear control.
Abstract
Artificial signalling networks (ASNs) are a computational approach inspired by the signalling processes inside cells that decode outside environmental information. Using evolutionary algorithms to induce complex behaviours, we show how chaotic dynamics in a conservative dynamical system can be controlled. Such dynamics are of particular interest as they mimic the inherent complexity of non-linear physical systems in the real world. Considering the main biological interpretations of cellular signalling, in which complex behaviours and robust cellular responses emerge from the interaction of multiple pathways, we introduce two ASN representations: a stand-alone ASN and a coupled ASN. In particular we note how sophisticated cellular communication mechanisms can lead to effective controllers, where complicated problems can be divided into smaller and independent tasks.
Year
DOI
Venue
2013
10.1016/j.biosystems.2013.03.006
Biosystems
Keywords
Field
DocType
Cellular signalling,Biochemical networks,Crosstalk,Evolutionary algorithms,Chaos control
Signalling,Biology,Evolutionary algorithm,Cellular communication,Physical system,Nonlinear control,Theoretical computer science,Computational model,Autonomous system (Internet),Artificial intelligence,Chaotic,Machine learning
Journal
Volume
Issue
ISSN
112
2
0303-2647
Citations 
PageRank 
References 
3
0.39
11
Authors
6
Name
Order
Citations
PageRank
Luis A. Fuente1294.28
Michael A. Lones216820.42
Alexander P. Turner3344.72
Susan Stepney4813113.21
Leo S. Caves551443.16
Andy M. Tyrrell662973.61