Name
Title | ||
|---|---|---|
Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. |
Abstract | ||
|---|---|---|
Human induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine. Generating iPSCs from immunologically immature newborn umbilical cord blood mononuclear cells (UCBMCs) is of great significance. Here we report generation of human iPSCs with great efficiency from UCBMCs using a dox-inducible lentiviral system carrying four Yamanaka factors. We generated these cells by optimizing the existing iPSC induction protocol. The UCBMC-derived iPSCs (UCB-iPSCs) have characteristics that are identical to pluripotent human embryonic stem cells (hESCs). This study highlights the use of UCBMCs to generate highly functional human iPSCs that could accelerate the development of cell-based regenerative therapy for patients suffering from various diseases. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1016/j.gpb.2013.08.002 | Genomics, Proteomics & Bioinformatics |
Keywords | Field | DocType |
Human UCBMCs,Human iPSCs,Dox-inducible lentiviral system | Cell culture,Induced pluripotent stem cell,Stem cell,Biology,Immunology,Regenerative medicine,Embryonic stem cell,Cell biology,Cellular differentiation,Peripheral blood mononuclear cell,Bioinformatics,Umbilical cord | Journal |
Volume | Issue | ISSN |
11 | 5 | 1672-0229 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Juan Wang | 1 | 0 | 0.34 |
| Qi Gu | 2 | 0 | 0.34 |
| Jie Hao | 3 | 0 | 0.34 |
| Donghui Bai | 4 | 0 | 0.34 |
| Lei Liu | 5 | 67 | 4.86 |
| Xiaoyang Zhao | 6 | 0 | 0.34 |
| Zhonghua Liu | 7 | 0 | 0.34 |
| Liu Wang | 8 | 0 | 0.34 |
| Q Zhou | 9 | 20 | 7.09 |