Name
Title | ||
|---|---|---|
A metadata-aware application for remote scoring and exchange of tissue microarray images. |
Abstract | ||
|---|---|---|
The use of tissue microarrays (TMA) and advances in digital scanning microscopy has enabled the collection of thousands of tissue images. There is a need for software tools to annotate, query and share this data amongst researchers in different physical locations.We have developed an open source web-based application for remote scoring of TMA images, which exploits the value of Microsoft Silverlight Deep Zoom to provide a intuitive interface for zooming and panning around digital images. We use and extend existing XML-based standards to ensure that the data collected can be archived and that our system is interoperable with other standards-compliant systems.The application has been used for multi-centre scoring of TMA slides composed of tissues from several Phase III breast cancer trials and ten different studies participating in the International Breast Cancer Association Consortium (BCAC). The system has enabled researchers to simultaneously score large collections of TMA and export the standardised data to integrate with pathological and clinical outcome data, thereby facilitating biomarker discovery. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1186/1471-2105-14-147 | BMC Bioinformatics |
Keywords | Field | DocType |
internet | Data mining,Metadata,XML,Information retrieval,Computer science,Software,Tissue Array Analysis,Tissue microarray,Bioinformatics,The Internet | Journal |
Volume | Issue | ISSN |
14 | 1 | 1471-2105 |
Citations | PageRank | References |
6 | 0.38 | 6 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Lorna Morris | 1 | 53 | 5.20 |
| Andrew Tsui | 2 | 20 | 3.03 |
| Charles Crichton | 3 | 101 | 9.36 |
| Steve Harris | 4 | 55 | 7.37 |
| Peter Maccallum | 5 | 9 | 1.14 |
| William J. Howat | 6 | 6 | 0.72 |
| Jim Davies | 7 | 673 | 80.95 |
| James Brenton | 8 | 47 | 4.14 |
| Carlos Caldas | 9 | 9 | 1.14 |