Paper Info
Title
Evaluation of Accuracy and Applicability of Protein Models: Retrospective Analysis of Biological and Biomedical Predictions.
Abstract
In order to study protein function and activity structural data is required. Since experimental structures are available for just a small fraction of all known protein sequences, computational methods such as protein modelling can provide useful information. Over the last few decades we have predicted, with homology modelling methods, the structures for numerous proteins. In this study we assess the structural quality and validity of the biological and medical interpretations and predictions made based on the models. All the models had correct scaffolding and were ranked at least as correct or good by numerical evaluators even though the sequence identity with the template was as low as 8%. The biological explanations made based on models were well in line with experimental structures and other experimental studies. Retrospective analysis of homology models indicates the power of protein modelling when made carefully from sequence alignment to model building and refinement. Modelling can be applied to studying and predicting different kinds of biological phenomena and according to our results it can be done so with success.
Year
DOI
Venue
2009
10.3233/ISB-2009-0408
In Silico Biology
Field
DocType
Volume
Sequence alignment,Biology,Ranking,Model building,Protein function,Bioinformatics
Journal
9
Issue
ISSN
Citations 
5-6
1434-3207
0
PageRank 
References 
Authors
0.34
6
2
Name
Order
Citations
PageRank
Sofia Khan100.68
Mauno Vihinen214526.73