Name
Title | ||
|---|---|---|
Practical Quality Assessment of Microarray Data by Simulation of Differential Gene Expression |
Abstract | ||
|---|---|---|
There are many methods for assessing the quality of microarray data, but little guidance regarding what to do when defective data is identified. Depending on the scientific question asked, discarding flawed data from a small experiment may be detrimental. Here we describe a novel quality assessment method that is designed to identify chips that should be discarded from an experiment. This technique simulates a set of differentially expressed genes and then assesses whether discarding each chip enhances or obscures the recovery of this known set. We compare our method to expert annotations derived using popular quality diagnostics and show, with examples, that the decision to discard a chip depends on the details of the particular experiment. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1007/978-3-642-01551-9_3 | ISBRA |
Keywords | Field | DocType |
differential gene expression,popular quality diagnostics,known set,defective data,novel quality assessment method,particular experiment,flawed data,practical quality assessment,small experiment,microarray data,scientific question,chip,simulation,microarray | Data mining,Microarray,Computer science,Microarray analysis techniques,Bioinformatics,Microarray databases | Conference |
Volume | ISSN | Citations |
5542 | 0302-9743 | 0 |
PageRank | References | Authors |
0.34 | 7 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Brian E. Howard | 1 | 26 | 4.24 |
| Beate Sick | 2 | 40 | 3.57 |
| Steffen Heber | 3 | 219 | 22.88 |