Paper Info
Title
Novel method for imaging biodegradable polymeric microparticles using MRI: application toward monitoring drug delivery
Abstract
We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.
Year
DOI
Keywords
2002
10.1109/ISBI.2002.1029214
biological organs,biomedical MRI,biomedical materials,cancer,drug delivery systems,patient monitoring,4 d,Gd,Gd-DTPA,biodegradable polymeric microparticles,biodegradable polymeric microparticles imaging method,bladder,blank particles,in vitro experiments,in vivo experiments,muco-adhesiveness,particle distribution,particle population,particle-based drug delivery systems,signal intensity,stability,urothelium,water
Field
DocType
ISBN
Biomedical engineering,Computer vision,Nanotechnology,Signal intensity,Population,Computer science,In vivo,Artificial intelligence,Drug delivery,Particle
Conference
0-7803-7584-X
Citations 
PageRank 
References 
0
0.34
0
Authors
8
Name
Order
Citations
PageRank
Hunter H. Chen101.01
Catherine Le Visage200.68
Bensheng Qiu3116.59
Xiangying Du401.69
Ronald Ouwerkerk500.34
Kam W. Leong612.33
Xiaoming Yang702.03
Le Visage, C.800.34