Title | ||
---|---|---|
A Mathematical Model of Prostate Tumor Growth Under Hormone Therapy with Mutation Inhibitor |
Abstract | ||
---|---|---|
This paper extends Jackson’s model describing the growth of a prostate tumor with hormone therapy to a new one with hypothetical
mutation inhibitors. The new model not only considers the mutation by which androgen-dependent (AD) tumor cells mutate into
androgen-independent (AI) ones but also introduces inhibition which is assumed to change the mutation rate. The tumor consists
of two types of cells (AD and AI) whose proliferation and apoptosis rates are functions of androgen concentration. The mathematical
model represents a free-boundary problem for a nonlinear system of parabolic equations, which describe the evolution of the
populations of the above two types of tumor cells. The tumor surface is a free boundary, whose velocity is equal to the cell’s
velocity there. Global existence and uniqueness of solutions of this model is proved. Furthermore, explicit formulae of tumor volume at any time t are found in androgen-deprived environment under the assumption of radial symmetry, and therefore the dynamics of tumor growth
under androgen-deprived therapy could be predicted by these formulae. Qualitative analysis and numerical simulation show that
controlling the mutation may improve the effect of hormone therapy or delay a tumor relapse. |
Year | DOI | Venue |
---|---|---|
2010 | 10.1007/s00332-009-9056-z | J. Nonlinear Science |
Keywords | Field | DocType |
Prostate cancer,Partial differential equations,Free-boundary problem,Hormone therapy,Inhibitors,35Q80,35R35,92C60 | Androgen,Mathematical optimization,Mutation rate,Mathematical analysis,Cancer research,Free boundary problem,Cell,Prostate,Prostate cancer,Hormone therapy,Mathematics,Mutation | Journal |
Volume | Issue | ISSN |
20 | 2 | 14321467 |
Citations | PageRank | References |
1 | 0.41 | 2 |
Authors | ||
3 |
Name | Order | Citations | PageRank |
---|---|---|---|
Youshan Tao | 1 | 22 | 7.04 |
Qian Guo | 2 | 14 | 5.02 |
Kazuyuki Aihara | 3 | 1909 | 333.03 |