Paper Info
Title
Caffeine reduces the initial dip in the visual BOLD response at 3 T.
Abstract
Localized changes in oxygen consumption related to increased neural activity can result in a small and transient “initial dip” of the blood oxygenation level-dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI). The initial dip has been of great interest to the fMRI community because it may provide a more accurate and localized measure of neural activity than the conventional BOLD signal increase. Although potentially useful as a technique for human brain mapping, the initial dip is not always detected and has been a source of some controversy. In this study, the BOLD response to a 4-s long visual stimulus was measured with a 3-T MRI system in 5 healthy volunteers both before and immediately after a 200-mg oral caffeine dose. The caffeine dose significantly (P < 0.001) reduced or eliminated the initial dip in all subjects. These findings suggest that caffeine usage may be a key factor in the detection of the initial dip in human fMRI studies.
Year
DOI
Venue
2006
10.1016/j.neuroimage.2006.03.005
NeuroImage
Field
DocType
Volume
Caffeine,Neuroscience,Functional magnetic resonance imaging,Anesthesia,Neural activity,Cognitive psychology,Psychology,Oxygenation,Human brain,Stimulus (physiology),Caffeine Dose
Journal
32
Issue
ISSN
Citations 
1
1053-8119
16
PageRank 
References 
Authors
1.46
5
2
Name
Order
Citations
PageRank
Yashar Behzadi139920.35
Thomas T Liu2102276.03