Title
Finding motifs in DNA sequences using low-dispersion sequences.
Abstract
Motif finding problems, abstracted as the planted (l, d)-motif finding problem, are a major task in molecular biology-finding functioning units and genes. In 2002, the random projection algorithm was introduced to solve the challenging (15, 4)-motif finding problem by using randomly chosen templates. Two years later, a so-called uniform projection algorithm was developed to improve the random projection algorithm by means of low-dispersion sequences generated by coverings. In this article, we introduce an improved projection algorithm called the low-dispersion projection algorithm, which uses low-dispersion sequences generated by developed almost difference families. Compared with the random projection algorithm, the low-dispersion projection algorithm can solve the (l, d)-motif finding problem with fewer templates without decreasing the success rate.
Year
DOI
Venue
2014
10.1089/cmb.2013.0054
JOURNAL OF COMPUTATIONAL BIOLOGY
Keywords
Field
DocType
random projection,developed almost difference family,uniform projection,motif finding,low-dispersion sequence
Random projection,Combinatorics,Dykstra's projection algorithm,Algorithm,Artificial intelligence,DNA sequencing,Template,Machine learning,Mathematics
Journal
Volume
Issue
ISSN
21.0
4
1066-5277
Citations 
PageRank 
References 
25
1.54
9
Authors
3
Name
Order
Citations
PageRank
Xun Wang1564.04
Ying Miao249143.85
M. Cheng315420.36