Name
Abstract | ||
|---|---|---|
We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an inverse power of the evolutionary time. In addition, our study of the trajectories shows that the out-of-equilibrium effects due to the evolutionary process are very weak. In particular, the distribution of genotypes is close to that arising during equilibrium stabilizing selection. As a consequence, the evolutionary dynamics leave almost no measurable out-of-equilibrium trace, only the transition genotypes (close to the border between different periods of stasis) have atypical mutational properties. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1142/S0219720010005075 | J. Bioinformatics and Computational Biology |
Keywords | DocType | Volume |
stabilizing selection,evolution,systems biology,rna structure,rna secondary structure,genotype,fitness landscape,phenotype,evolutionary dynamics | Journal | 8 |
Issue | ISSN | Citations |
6 | 1757-6334 | 1 |
PageRank | References | Authors |
0.35 | 2 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Petr Sulc | 1 | 8 | 2.42 |
| Andreas Wagner | 2 | 1 | 0.35 |
| Olivier C Martin | 3 | 192 | 19.20 |