Title
Semi-supervised learning of sparse linear models in mass spectral imaging
Abstract
We present an approach to learn predictive models and perform variable selection by incorporating structural information from Mass Spectral Imaging (MSI) data. We explore the use of a smooth quadratic penalty to model the natural ordering of the physical variables, that is the mass-to-charge (m/z) ratios. Thereby, estimated model parameters for nearby variables are enforced to smoothly vary. Similarly, to overcome the lack of labeled data we model the spatial proximity among spectra by means of a connectivity graph over the set of predicted labels. We explore the usefulness of this approach in a mouse brain MSI data set.
Year
DOI
Venue
2010
10.1007/978-3-642-16001-1_28
PRIB
Keywords
Field
DocType
semi-supervised learning,mass spectral imaging,sparse linear model,connectivity graph,physical variable,smooth quadratic penalty,mouse brain msi data,predictive model,estimated model parameter,nearby variable,structural information,spatial proximity,linear model,sparsity,convex optimization,spatial information,variable selection,prediction model,regularization,graph laplacian,connected graph,spectral imaging,semi supervised learning
Spatial analysis,Laplacian matrix,Spectral imaging,Semi-supervised learning,Feature selection,Pattern recognition,Computer science,Linear model,Regularization (mathematics),Artificial intelligence,Convex optimization,Machine learning
Conference
Volume
ISSN
ISBN
6282
0302-9743
3-642-16000-X
Citations 
PageRank 
References 
2
0.72
4
Authors
6
Name
Order
Citations
PageRank
Fabian Ojeda1654.60
Marco Signoretto21559.10
Raf Van de Plas3553.67
Etienne Waelkens472.06
Bart De Moor55541474.71
Johan A K Suykens62346241.14