Paper Info
Title
State-dependent differences between functional and effective connectivity of the human cortical motor system.
Abstract
Neural processing is based on interactions between functionally specialized areas that can be described in terms of functional or effective connectivity. Functional connectivity is often assessed by task-free, resting-state functional magnetic resonance imaging (fMRI), whereas effective connectivity is usually estimated from task-based fMRI time-series. To investigate whether different connectivity approaches assess similar network topologies in the same subjects, we scanned 36 right-handed volunteers with resting-state fMRI followed by active-state fMRI involving a hand movement task. Time-series information was extracted from identical locations defined from individual activation maxima derived from the motor task. Dynamic causal modeling (DCM) was applied to the motor task time-series to estimate endogenous and context-dependent effective connectivity. In addition, functional connectivity was computed for both the rest and the motor task condition by means of inter-regional time-series correlations. At the group-level, we found strong interactions between the motor areas of interest in all three connectivity analyses. However, although the sample size warranted 90% power to detect correlations of medium effect size, resting-state functional connectivity was only weakly correlated with both task-based functional and task-based effective connectivity estimates for corresponding region-pairs. By contrast, task-based functional connectivity showed strong positive correlations with DCM effective connectivity parameters. In conclusion, resting-state and task-based connectivity reflect different components of functional integration that particularly depend on the functional state in which the subject is being scanned. Therefore, resting-state fMRI and DCM should be used as complementary measures when assessing functional brain networks.
Year
DOI
Venue
2013
10.1016/j.neuroimage.2012.11.027
NeuroImage
Keywords
Field
DocType
Dynamic causal modeling,fMRI,Intrinsic connectivity,Resting-state
Neuroscience,Resting state fMRI,Cognitive psychology,Motor cortex,Artificial intelligence,Motor system,Functional integration,Causal model,Functional magnetic resonance imaging,Nerve net,Connectome,Machine learning,Mathematics
Journal
Volume
ISSN
Citations 
67
1053-8119
1
PageRank 
References 
Authors
0.37
19
3
Name
Order
Citations
PageRank
Anne K. Rehme1434.40
Simon B. Eickhoff2129779.68
Christian Grefkes317116.40