Title
Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A.
Abstract
Alterations of connectivity are central to the systems-level pathophysiology of schizophrenia. One of the best-established genome-wide significant risk variants for this highly heritable disorder, the rs1344706 single nucleotide polymorphism in ZNF804A, was recently shown to modulate connectivity in healthy carriers during working memory (WM) in a pattern mirroring that which was found in overt disease. However, it was unclear whether this finding is specific to WM or if it is present regardless of cognitive state. Therefore, we examined genotype effects on connectivity in healthy carriers during rest and an emotion processing task without WM component.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2010.10.012
NeuroImage
Keywords
Field
DocType
working memory,single nucleotide polymorphism,functional imaging,genetics
Voxel,Developmental psychology,Allele,Psychosis,Working memory,Psychology,Functional imaging,Single-nucleotide polymorphism,Cognition,Schizophrenia
Journal
Volume
Issue
ISSN
54
3
1053-8119
Citations 
PageRank 
References 
10
0.92
9
Authors
13
Name
Order
Citations
PageRank
Christine Esslinger11105.45
P Kirsch21157.55
Leila Haddad31105.45
Daniela Mier41105.92
Carina Sauer5954.41
Susanne Erk61259.64
Knut Schnell7232.11
Claudia Arnold8100.92
Stephanie H Witt9122.47
Marcella Rietschel10275.81
Sven Cichon11121.64
Henrik Walter1219825.70
Andreas Meyer-Lindenberg1325318.54