Title
Computing scalable multivariate glocal invariants of large (brain-) graphs.
Abstract
Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices correspond to neurons (or collections thereof) and edges correspond to structural or functional connections between them. To explore the variability of connectomes-to address both basic science questions regarding the structure of the brain, and medical health questions about psychiatry and neurology-one can study the topological properties of these brain-graphs. We define multivariate glocal graph invariants: these are features of the graph that capture various local and global topological properties of the graphs. We show that the collection of features can collectively be computed via a combination of daisy-chaining, sparse matrix representation and computations, and efficient approximations. Our custom open-source Python package serves as a back-end to a Web-service that we have created to enable researchers to upload graphs, and download the corresponding invariants in a number of different formats. Moreover, we built this package to support distributed processing on multicore machines. This is therefore an enabling technology for network science, lowering the barrier of entry by providing tools to biologists and analysts who otherwise lack these capabilities. As a demonstration, we run our code on 120 brain-graphs, each with approximately 16M vertices and up to 90M edges.
Year
DOI
Venue
2013
10.6084/m9.figshare.1284168
IEEE Global Conference on Signal and Information Processing
Keywords
DocType
Volume
distributed processing,web services,graph theory,public domain software,sparse matrices
Journal
abs/1312.4318
ISSN
Citations 
PageRank 
2376-4066
3
0.61
References 
Authors
4
9
Name
Order
Citations
PageRank
Disa Mhembere1635.42
William Gray Roncal2388.25
Daniel L. Sussman3366.10
Carey E. Priebe4505108.56
Rex E. Jung510210.63
Sephira Ryman671.11
R. J. Vogelstein726924.60
Joshua T. Vogelstein827331.99
Randal Burns91955115.15