Name
Title | ||
|---|---|---|
SNOMED CT normal form and HL7 RIM binding to normalize clinical data from cancer trials |
Abstract | ||
|---|---|---|
Current research in oncology, require the involvement of several institutions participating in clinical trials. Heterogeneities of data formats and models require advanced methods to achieve semantic interoperability and provide sustainable solutions. In this field, the EU funded INTEGRATE project aims to develop the basic knowledge to allow data sharing of data from post-genomic clinical trials on breast cancer. In this paper, we describe the procedure implemented in this project and the required binding between relevant terminologies such as SNOMED CT and an HL7 v3 Reference Information Model (RIM)-based data model. After following the HL7 recommendations, we also describe the main issues of this process and the proposed solution, such as concept overlapping and coverage of the domain terminology. Despite the fact that the data from this domain presents a high level of heterogeneity, the methods and solutions introduced in this paper have been successfully applied within the INTEGRATE project context. Results suggest that the level of semantic interoperability required to manage patient data in modern clinical trials on breast cancer can be achieved with the proposed methodology. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1109/BIBE.2013.6701688 | Bioinformatics and Bioengineering |
Keywords | Field | DocType |
cancer,computerised tomography,genomics,gynaecology,medical image processing,open systems,EU,HL7 RIM binding,HL7 v3 reference information model-based data model,INTEGRATE project,SNOMED CT normal form,breast cancer,cancer trials,clinical data,concept overlapping,data formats,domain terminology,oncology,post-genomic clinical trials,semantic interoperability | Terminology,Computer science,Data sharing,Clinical trial,Semantic interoperability,Information model,Bioinformatics,Open system (systems theory),SNOMED CT,Data model | Conference |
ISSN | Citations | PageRank |
2471-7819 | 0 | 0.34 |
References | Authors | |
0 | 10 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Antonio Rico-Diez | 1 | 3 | 0.87 |
| Santiago Aso | 2 | 3 | 0.87 |
| david perezrey | 3 | 135 | 20.28 |
| Raúl Alonso-Calvo | 4 | 107 | 14.64 |
| Anca I. D. Bucur | 5 | 167 | 20.83 |
| Brecht Claerhout | 6 | 39 | 11.63 |
| Victor Maojo | 7 | 333 | 53.22 |
| Rico-Diez, A. | 8 | 0 | 0.34 |
| Perez-Rey, D. | 9 | 0 | 0.34 |
| Alonso-Calvo, R. | 10 | 0 | 0.34 |