Paper Info
Title
Allele Frequency Net: A Database And Online Repository For Immune Gene Frequencies In Worldwide Populations
Abstract
The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608 813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chain-related genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. The resource has been used in a wide variety of contexts, including clinical applications (histocompatibility, immunology, epidemiology and pharmacogenetics) and population genetics. Demographic information, frequency data and searching tools can be freely accessed through the website.
Year
DOI
Venue
2011
10.1093/nar/gkq1128
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
nucleic,internet,genotype,allele frequency,major histocompatibility complex,gene frequency,haplotypes
Allele,Allele frequency net database,Biology,Allele frequency,Haplotype,Population genetics,Human leukocyte antigen,Histocompatibility,Genetics,Transplantation
Journal
Volume
Issue
ISSN
39
Database issue
0305-1048
Citations 
PageRank 
References 
8
1.42
2
Authors
4
Name
Order
Citations
PageRank
Faviel F Gonzalez-Galarza1163.13
Stephen Christmas281.42
Derek Middleton3132.36
Andrew R. Jones4757.65