Paper Info
Title
Evolution of Intracellular Ca2 + Waves from about 10,000 RyR Clusters: Towards Solving a Computationally Daunting Task
Abstract
Detailed knowledge of spatial-temporal behaviours of intracellular calcium dynamics is very important in understanding excitation-contraction coupling of cardiac myocytes under both normal and pathological conditions, such as initiation and propagation of spontaneous calcium waves. A full cell simulation integrating about 10,000 Ca2 +  release units (CRUs) in a typical cardiac myocyte is considered a multi-scale, computationally demanding problem. In this paper, we imported an experimentally obtained spatial distribution of Ryanodine Receptor (RyR) clusters into a spatially extended, stochastic model of intracellular Ca2 +  dynamics, to investigate the role of the structural bifurcation of Z-disks on the initiation and propagation of intracellular Ca2 +  waves from spatially symmetric Ca2 +  sparks. Besides, we also proposed a simple parallelization strategy to increase computational speed for this chanllenging problem in cardiac modelling.
Year
DOI
Venue
2009
10.1007/978-3-642-01932-6_2
FIMH '09 Proceedings of the 5th International Conference on Functional Imaging and Modeling of the Heart
Keywords
Field
DocType
spontaneous calcium wave,intracellular ca2,ryanodine receptor,computationally daunting task,cardiac myocytes,ryr clusters,computational speed,spatially symmetric ca2,cardiac modelling,intracellular calcium dynamic,typical cardiac myocyte,chanllenging problem,stochastic model,intracellular calcium,parallel computing,excitation contraction coupling
Cluster (physics),Calcium in biology,Biological system,Simulation,Intracellular,Stochastic modelling,Calcium Waves,Ryanodine receptor,Physics,Bifurcation
Conference
Volume
ISSN
Citations 
5528
0302-9743
0
PageRank 
References 
Authors
0.34
2
6
Name
Order
Citations
PageRank
Pan Li100.34
Wenjie Wei2122.33
Xing Cai3519.54
Christian Soeller400.68
Mark B. Cannell531.06
Arun V. Holden65220.71