Name
Title | ||
|---|---|---|
The "Latent Membrane Permeability" Concept: QSPR Analysis of Inter/Intralaboratorically Variable Caco-2 Permeability |
Abstract | ||
|---|---|---|
Caco-2 cell monolayers grown on a filter support are the most widely used systems for predicting intestinal absorption. However, inter- and intralaboratory variability in Caco-2 permeability makes it difficult to analyze any QSPR relationship for a large number of compounds. We proposed the "latent membrane permeability" concept, assuming that all Caco-2 permeability data sets share a hidden, common relationship between their membrane permeability and physicochemical properties. An iterative calculation method was developed to handle this conceptual approach and applied to the analysis of Caco-2 permeability data sets from different sources. A thorough statistical analysis revealed that the "latent membrane permeability" concept be reasonable. |
Year | DOI | Venue |
|---|---|---|
2002 | 10.1021/ci010317y | JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES |
Field | DocType | Volume |
Quantitative structure–activity relationship,Analytical chemistry,Biological system,Computational chemistry,Chemistry,Membrane,Permeability (electromagnetism),Statistical analysis | Journal | 42 |
Issue | ISSN | Citations |
2 | 0095-2338 | 1 |
PageRank | References | Authors |
0.38 | 0 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Fumiyoshi Yamashita | 1 | 15 | 3.67 |
| Shin-ichi Fujiwara | 2 | 1 | 0.38 |
| Mitsuru Hashida | 3 | 10 | 2.71 |