Paper Info
Title
ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes
Abstract
Motivation: Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome alignments produced by the ECR Browser. ECRbase features a database of syntenic blocks that recapitulate the evolution of rearrangements in vertebrates and a comprehensive collection of promoters in all vertebrate genomes generated using multiple sources of gene annotation. The database also contains a collection of annotated transcription factor binding sites (TFBSs) in evolutionary conserved and promoter elements. ECRbase currently includes human, rhesus macaque, dog, opossum, rat, mouse, chicken, frog, zebrafish and fugu genomes. It is freely accessible at http://ecrbase.dcode.org. Contact: ovcharenko1@llnl.gov Supplementary information: Supplementary Data are available at Bioinformatics online.
Year
DOI
Venue
2007
10.1093/bioinformatics/btl546
Bioinformatics
Keywords
Field
DocType
evolutionary conservation,transcription factor binding site,dna sequence,chicken
Genome,Synteny,Promoter,Conserved sequence,DNA binding site,Biology,DNA sequencing,Bioinformatics,Fugu,Gene Annotation,Database
Journal
Volume
Issue
ISSN
23
1
1367-4803
Citations 
PageRank 
References 
10
0.65
4
Authors
2
Name
Order
Citations
PageRank
Gabriela G Loots1879.49
Ivan Ovcharenko216617.49