Title
DIDO: a disease-determinants ontology from web sources
Abstract
This paper introduces DIDO, a system providing convenient access to knowledge about factors involved in human diseases, automatically extracted from textual Web sources. The knowledge base is bootstrapped by integrating entities from hand-crafted sources like MeSH and OMIM. As these are short on relationships between dierent types of biomedical entities, DIDO employs flexible and robust pattern learning and constraint-based reasoning methods to automatically extract new relational facts from textual sources. These facts can then be iteratively added to the knowledge base. The result is a semantic graph of typed entities and relations between diseases, their symptoms, and their factors, with emphasis on environmental factors but covering also molecular determinants. We demonstrate the value of DIDO for knowledge discovery about causal factors and properties of complex diseases, including factor-disease chains.
Year
DOI
Venue
2011
10.1145/1963192.1963298
WWW (Companion Volume)
Keywords
Field
DocType
complex disease,causal factor,dierent type,textual web source,knowledge discovery,constraint-based reasoning method,biomedical entity,web source,knowledge base,textual source,disease-determinants ontology,convenient access,relation extraction,ontology
Ontology,Data mining,Disease,World Wide Web,Computer science,Bootstrapping,Knowledge-based systems,Knowledge extraction,Knowledge base,DIDO,Relationship extraction
Conference
Citations 
PageRank 
References 
4
0.43
9
Authors
5
Name
Order
Citations
PageRank
Victoria Nebot Romero140.43
Min Ye240.43
Mario Albrecht340.43
Jae-Hong Eom4868.91
Gerhard Weikum5127102146.01