Title
Flexible case-based retrieval for comparative genomics
Abstract
Comparative genomics represents a key instrument to discover or validate phylogenetic relationships, to give insights on genome evolution, and to infer metabolic functions of a given organism. A tool for properly supporting comparative genomics is of paramount importance in several application domains.We have developed a tool for supporting customized comparative genomics searches. The tool is based on the retrieval step of the Case-Based Reasoning methodology. It takes advantage of an abstraction technique similar to Temporal Abstractions, thus allowing us to neglect irrelevant details.By means of our tool, retrieval is made flexible by the use of abstractions, and efficient by the use of proper taxonomic index structures. Moreover, end-users are allowed to progressively relax or refine their queries in an interactive way. The tool functionalities are exemplified referring to the study of endobacteria living in arbuscular mycorrhizal fungi.
Year
DOI
Venue
2013
10.1007/s10489-012-0399-z
Appl. Intell.
Keywords
DocType
Volume
Comparative genomics,Case-Based Reasoning,Flexible retrieval,Index-based retrieval,Interactivity
Journal
39
Issue
ISSN
Citations 
1
0924-669X
0
PageRank 
References 
Authors
0.34
23
4
Name
Order
Citations
PageRank
Stefania Montani190181.42
Giorgio Leonardi217920.36
Stefano Ghignone301.35
Luisa Lanfranco401.35