Paper Info
Title
The Tp53 Website: An Integrative Resource Centre For The Tp53 Mutation Database And Tp53 Mutant Analysis
Abstract
A novel resource centre for TP53 mutations and mutants has been developed(http://p53.fr). TP53 gene dysfunction can be found in the majority of human cancer types. The potential use of TP53 mutation as a biomarker for clinical studies or exposome analysis has led to the publication of thousands of reports describing the TP53 gene status in > 10 000 tumours. The UMD TP53 mutation database was created in 1990 and has been regularly updated. The 2012 release of the database has been carefully curated, and all suspicious reports have been eliminated. It is available either as a flat file that can be easily manipulated or as novel multi-platform analytical software that has been designed to analyse various aspects of TP53 mutations. Several tools to ascertain TP53 mutations are also available for download. We have developed TP53MULTLoad, a manually curated database providing comprehensive details on the properties of 2549 missense TP53 mutants. More than 100 000 entries have been arranged in 39 different activity fields, such as change of transactivation on various promoters, apoptosis or growth arrest. For several hot spot mutants, multiple gain of function activities are also included. The database can be easily browsed via a graphical user interface.
Year
DOI
Venue
2013
10.1093/nar/gks1033
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
internet,mutation,nucleic
Missense mutation,Biology,Flat file database,Mutant,Genetics,Database,Exposome,Mutation
Journal
Volume
Issue
ISSN
41
D1
0305-1048
Citations 
PageRank 
References 
0
0.34
2
Authors
7
Name
Order
Citations
PageRank
Bernard Leroy100.34
Jean Louis Fournier200.34
Chikashi Ishioka300.34
Paola Monti400.34
Alberto Inga500.34
G Fronza600.68
T Soussi7219.94