Title
Measurement of cell and bacterial activity using array-based ISFET Chemical Current-Conveyor in weak-inversion
Abstract
The ISFET chemical current conveyor (CCCII+) was first reported by the authors at ISCAS 2008. In this paper a new application of the CCCII+ is presented, namely to provide a direct means of measuring cell and bacterial activity. The measurement system is based on an array of unmodified ISFET CCCII+ sensors each of which when operated in weak inversion gives an output corresponding to the time derivative of hydrogen ions. Combining each of the CCCII+ time derivative outputs in the array using the analog computational versatility of the CCCII+ current output stage provides a signal corresponding to cell and bacterial activity. The design has been fully simulated using Triple-well 0.18-μm CMOS technology and the results presented in this paper show that a viable system for direct measurement of cell and bacterial activity can be obtain, further confirming the utility of the CCCII+ for another biochemical sensing application.
Year
DOI
Venue
2012
10.1109/ISCAS.2012.6271687
ISCAS
Keywords
Field
DocType
iscas 2008,biosensors,cmos integrated circuits,hydrogen ions,current output stage,unmodified isfet cccii+ sensor array,triple-well cmos technology,weak-inversion operation,microorganisms,biochemical sensing application,analog computational versatility,size 0.18 mum,ion sensitive field effect transistors,chemical sensors,bacterial activity measurement,cell measurement,array-based isfet chemical current-conveyor,time derivative outputs,current conveyors,sensor arrays,capacitors,chemicals,impedance,sensors
ISFET,Capacitor,System of measurement,Computer science,Electronic engineering,Electrical impedance,CMOS,Time derivative,Biosensor,Current conveyor
Conference
ISSN
ISBN
Citations 
0271-4302
978-1-4673-0218-0
0
PageRank 
References 
Authors
0.34
2
5
Name
Order
Citations
PageRank
Panavy Pookaiyaudom110.82
Apisak Worapishet28520.67
F. J. Lidgey31310.51
Khaled Hayatleh41012.62
Christofer Toumazou526559.06