Title
Consensus versus disagreement in imaging research: a case study using the LIDC database.
Abstract
Traditionally, image studies evaluating the effectiveness of computer-aided diagnosis (CAD) use a single label from a medical expert compared with a single label produced by CAD. The purpose of this research is to present a CAD system based on Belief Decision Tree classification algorithm, capable of learning from probabilistic input (based on intra-reader variability) and providing probabilistic output. We compared our approach against a traditional decision tree approach with respect to a traditional performance metric (accuracy) and a probabilistic one (area under the distance-threshold curve-AuC(dt)). The probabilistic classification technique showed notable performance improvement in comparison with the traditional one with respect to both evaluation metrics. Specifically, when applying cross-validation technique on the training subset of instances, boosts of 28.26% and 30.28% were noted for the probabilistic approach with respect to accuracy and AuC(dt), respectively. Furthermore, on the validation subset of instances, boosts of 20.64% and 23.21% were noted again for the probabilistic approach with respect to the same two metrics. In addition, we compared our CAD system results with diagnostic data available for a small subset of the Lung Image Database Consortium database. We discovered that when our CAD system errs, it generally does so with low confidence. Predictions produced by the system also agree with diagnoses of truly benign nodules more often than radiologists, offering the possibility of reducing the false positives.
Year
DOI
Venue
2012
10.1007/s10278-011-9445-3
J. Digital Imaging
Keywords
Field
DocType
Chest CT,Computer-aided diagnosis (CAD),Feature extraction,Image analysis,Machine learning,Radiographic image interpretation,Computer-assisted
Data mining,Decision tree,Computer science,Artificial intelligence,Probabilistic logic,CAD,Computer vision,Performance metric,Feature extraction,Probabilistic classification,Database,Medical diagnosis,Machine learning,False positive paradox
Journal
Volume
Issue
ISSN
25
3
1618-727X
Citations 
PageRank 
References 
2
0.40
10
Authors
5
Name
Order
Citations
PageRank
Dmitry Zinovev130.79
Yujie Duo220.40
Daniela Stan Raicu346946.22
Jacob D. Furst454556.63
Samuel G. Armato III5869.72