Name
Title | ||
|---|---|---|
Peptide sequence tag generation for tandem mass spectra containing post-translational modifications. |
Abstract | ||
|---|---|---|
Tandem mass spectrometry is a popular tool for the identification of peptide sequences. In this paper, we present a method for a rapid generation of short peptide sequences via tandem mass spectrometry based on a graph search method. The approach takes advantage of several pairs of peaks that have high intensities. We proposed a Pair Peak value Set (PPS) and used the pair peak values of highest intensities as the root of a tree. The other nodes are viewed as the reference nodes to search the most promising path. We aimed to determine the peptide sequences for MS/MS spectra that have low signal-to-noise ratios. Our experiment on 2420 experimental MS/MS spectra with two PTMs shows that our algorithm achieves better accuracy than the PepNovo approach with higher efficiency. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1504/IJCBDD.2012.049209 | Int. J. Comput. Biol. Drug Des. |
Keywords | Field | DocType |
post translational modification | Graph,Tandem,Peptide sequence tag,Mass spectrum,Tandem mass spectrometry,Peptide,Posttranslational modification,Chemistry,Bioinformatics,Peptide mass fingerprinting | Journal |
Volume | Issue | ISSN |
5 | 3/4 | 1756-0756 |
Citations | PageRank | References |
0 | 0.34 | 2 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Hui Li | 1 | 3 | 5.46 |
| Chun-Mei Liu | 2 | 245 | 41.30 |