Paper Info
Title
Structural similarity of genetically interacting proteins.
Abstract
The study of gene mutants and their interactions is fundamental to understanding gene function and backup mechanisms within the cell. The recent availability of large scale genetic interaction networks in yeast and worm allows the investigation of the biological mechanisms underlying these interactions at a global scale. To date, less than 2% of the known genetic interactions in yeast or worm can be accounted for by sequence similarity.Here, we perform a genome-scale structural comparison among protein pairs in the two species. We show that significant fractions of genetic interactions involve structurally similar proteins, spanning 7-10% and 14% of all known interactions in yeast and worm, respectively. We identify several structural features that are predictive of genetic interactions and show their superiority over sequence-based features.Structural similarity is an important property that can explain and predict genetic interactions. According to the available data, the most abundant mechanism for genetic interactions among structurally similar proteins is a common interacting partner shared by two genetically interacting proteins.
Year
DOI
Venue
2008
10.1186/1752-0509-2-69
BMC systems biology
Keywords
Field
DocType
bioinformatics,structural similarity,interaction network,algorithms,genetics,systems biology
Sequence alignment,Structural alignment,Gene,Biology,Systems biology,Genomics,Mechanism (biology),Structural similarity,Bioinformatics,Protein structure
Journal
Volume
Issue
ISSN
2
1
1752-0509
Citations 
PageRank 
References 
4
0.35
2
Authors
6
Name
Order
Citations
PageRank
Oranit Dror113612.48
Dina Schneidman-Duhovny218618.96
Alexandra Shulman-peleg330721.59
Ruth Nussinov4845113.97
Haim J Wolfson51837495.25
Roded Sharan62792186.61