Name
Title | ||
|---|---|---|
Validation of 3D assessment of MR imaging-guided percutaneous cryotherapy of a soft-tissue metastasis |
Abstract | ||
|---|---|---|
To assess the response to image-guided thermal therapies, 3D analysis of both the tumor and ablation effects are needed. Assessment can be provided by 3D computer models created by segmenting tissues from 2D cross-sectional images. We present a statistical evaluation of manual segmentation applied to a case of percutaneous cryotherapy. Pre- and post-procedural MR images of a treated soft-tissue metastasis were analyzed. Tumor and cryonecrosis regions were segmented 5 times each by 3 observers. These 45 3D models were then evaluated using an algorithm (STAPLE: Simultaneous Truth and Performance Level Estimation), yielding a measure of the sensitivity and specificity of the models. Data were analyzed to assess both the variability of an individual observer and the inter-observer variability. The intra-observer sensitivities for the 3 observers for the pre-procedural tumor were 0.91, 0.94, 0.90. Similar results were found for post-procedural tumor and cryonecrosis. The mean overall inter-observer sensitivity (bias removed) for the pre-procedural tumor was 0.95; it was 0.96 and 0.97 for the post-procedural tumor and the cryonecrosis, respectively. A single estimate of the “true segmentation” 3D model is likely closest to reality. This method is effective for the validation of multi-observer repeated 3D segmentations and may be especially significant in clinical practice. |
Year | DOI | Venue |
|---|---|---|
2004 | 10.1016/j.ics.2004.03.231 | International Congress Series |
Keywords | Field | DocType |
Image-guided therapy,Cryotherapy,Tumor ablation,Musculoskeletal neoplasm,Therapy,Magnetic resonance imaging (MRI) | Mr imaging,Segmentation,Clinical Practice,Soft tissue metastasis,Ablation,Radiology,Image-Guided Therapy,Cryotherapy,Medicine,Percutaneous | Conference |
Volume | ISSN | Citations |
1268 | 0531-5131 | 0 |
PageRank | References | Authors |
0.34 | 2 | 8 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Christian P Zentai | 1 | 0 | 0.34 |
| Daniel Worku | 2 | 0 | 0.34 |
| Kemal Tuncali | 3 | 82 | 13.51 |
| Kelly H. Zou | 4 | 750 | 54.43 |
| Paul R. Morrison | 5 | 6 | 1.76 |
| Simon K. Warfield | 6 | 2825 | 229.11 |
| R.M.M Seibel | 7 | 0 | 0.34 |
| Stuart G. Silverman | 8 | 59 | 9.62 |