Title
Analytical model of initial fluid infusion by a microneedle drug delivery system
Abstract
An analytical model is proposed to calculate the initial infusion of a microneedle array driven by a micropump. By assuming the initial infusion of each microneedle undergoes a spherical expansion, the model is able to calculate the time-varying expansion radius, as well as the flow rate and infusion pressure, provided that the material properties and the microneedle system parameters are known. For a selected piezoelectric micropump, our results show that the expansion under the skin stops and the flow rate drops to zero in a short time. We also found that the initial flow characteristics are strongly influenced by the material properties of the skin and parameters of the drug deliver system.
Year
DOI
Venue
2011
10.1109/BMEI.2011.6098420
BMEI
Keywords
Field
DocType
spherical expansion,microneedle array,material properties,time-varying expansion radius,biomems,initial fluid infusion,microneedle,microneedle drug delivery system,piezoelectric micropump,flow rate,micropumps,biomedical equipment,micropump,analytical model,piezoelectric devices,drug delivery systems,component,skin,mathematical model,solids
Biomedical engineering,Computer vision,Nanotechnology,Computer science,Flow (psychology),Biomedical equipment,Micropump,Artificial intelligence,Material properties,Drug delivery,Volumetric flow rate,Piezoelectricity
Conference
Volume
Issue
ISBN
2
null
978-1-4244-9351-7
Citations 
PageRank 
References 
0
0.34
1
Authors
3
Name
Order
Citations
PageRank
Fenglei Yang182.50
Kai Chen200.34
Zhigang Feng3112.86