Name
Title | ||
|---|---|---|
Imaging the early cerebral blood flow changes in rat middle cerebral artery occlusion stroke model. |
Abstract | ||
|---|---|---|
Intraluminal middle cerebral artery occlusion (MCAO) model in rats has been widely used to mimic human ischemic stroke and serves as an indispensable tool in the stroke research field. One limitation of this model is its high variability in infarct volume. The cerebral blood flow (CBF) information after cerebrovascular occlusion may reflect the availability of collateral circulation, which serves as a key factor for brain infarct volume. Laser speckle contrast imaging (LSCI) is a valuable tool for full-field imaging of CBF with high spatial and temporal resolution. In this paper, we investigated the spatio-temporal changes of CBF in rat MCAO stroke model using our self-developed real-time LSCI system. CBF images of adult male Sprague Dawley rats (n=13) were recorded before surgery, during first 1.5 hours after surgery, and 24 hours after stroke. We compared the CBF changes of different functional vessels during this period. In the ipsilateral hemisphere, CBF of veins and arteries both decreased as expected, while CBF of veins increased after occlusion in the contralateral hemisphere. Moreover, we found a linear correlation between early-stage CBF after occlusion and brain infarct volume, which can be utilized for surgery guidance to improve the uniformity of rat MCAO stroke models. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1109/EMBC.2012.6346510 | EMBC |
Keywords | Field | DocType |
cbf image,functional vessel,cerebral blood flow,neurophysiology,laser speckle contrast imaging,real-time lsci system,haemorheology,cbf artery,blood vessels,rat middle cerebral artery occlusion stroke model,full-field imaging,brain infarct volume,time 1.5 h,contralateral hemisphere,rat mcao stroke model,ipsilateral hemisphere,collateral circulation,cbf spatio-temporal change,laser applications in medicine,cerebrovascular occlusion,time 24 h,adult male sprague dawley rat,surgery,cbfvein,haemodynamics | Hemodynamics,Linear correlation,Occlusion,Lumen (anatomy),Anesthesia,Middle cerebral artery,Stroke,Collateral circulation,Cerebral blood flow,Medicine | Conference |
Volume | Issue | ISSN |
2012 | null | 1557-170X |
ISBN | Citations | PageRank |
978-1-4577-1787-1 | 1 | 0.63 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Shuping Zhu | 1 | 3 | 1.54 |
| Yao Li | 2 | 1 | 1.30 |
| Hongyang Lu | 3 | 1 | 0.96 |
| Hangdao Li | 4 | 2 | 1.70 |
| Shanbao Tong | 5 | 205 | 24.36 |