Title
Network-based modeling for analyzing the human skin microbiome
Abstract
Microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. Advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. A microbial community similarity function of skin sites was defined to analysis the topographical diversity of microbial community in this paper. We found that the moist skin sites and sebaceous skin sites easily group together respectively with furthest-neighbor clustering algorithm, which shows that the moist skin sites and sebaceous skin sites have their respective microenvironments. We also introduced a bipartite network modeling method and network aligning algorithm. The network analysis revealed that the microbial species of moist skin sites is more than that of sebaceous skin sites, and resampled volunteers were more like themselves over time than they were like other volunteers. These results show that our network analysis methods are effective for researching the complexity and stability of the human skin microbial community.
Year
DOI
Venue
2010
10.1109/BIBMW.2010.5703784
Bioinformatics and Biomedicine Workshops
Keywords
DocType
Volume
innocuous symbiotic organisms,microbiology,human skin microbiome analysis,human skin,microorganisms,network aligning algorithm,bipartite network modeling method,furthest neighbor clustering algorithm,bipartite network modeling,sebaceous skin sites,moist skin sites,complex networks,immunology,physiological models,biology computing,microbial community similarity,network aligning,microenvironments,microbes,network based modeling,microbial community similarity function,network analysis,microbial virulence molecular mechanisms,host-microbe interaction,skin,microbial community topographical diversity,potential pathogens,clustering algorithms,molecular mechanics,algorithm design and analysis,bioinformatics,network model,microbial community
Conference
null
Issue
ISSN
ISBN
null
null
978-1-4244-8304-4
Citations 
PageRank 
References 
0
0.34
4
Authors
5
Name
Order
Citations
PageRank
YingZhuo Wei100.34
Shao-Wu Zhang218934.00
Chunhui Chunhui300.34
Feng Yang4184.42
quan pan523917.11