Name
Title | ||
|---|---|---|
Measurements of the left atrium and pulmonary veins for analysis of reverse structural remodeling following cardiac ablation therapy |
Abstract | ||
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Rationale and objectivesGeometric analysis of the left atrium and pulmonary veins is important for assessing reverse structural remodeling following cardiac ablation therapy. Most volumetric analysis techniques, however, require laborious manual tracing of image cross-sections. Pulmonary vein diameters are typically measured at the junction between the left atrium and pulmonary veins, called the pulmonary vein ostia, with manually drawn lines on volume renderings or in image slices. In this work, we describe a technique for making semi-automatic measurements of left atrial volume and pulmonary vein diameters from high resolution CT scans and demonstrate its use for analyzing reverse structural remodeling following cardiac ablation therapy. MethodsThe left atrium and pulmonary veins are segmented from high-resolution computed tomography (CT) volumes using a 3D volumetric approach and cut planes are interactively positioned to separate the pulmonary veins from the body of the left atrium. Left atrial volume and pulmonary vein ostial diameters are then automatically computed from the segmented structures. Validation experiments are conducted to evaluate accuracy and repeatability of the measurements. Accuracy is assessed by comparing left atrial volumes computed with the proposed methodology to a manual slice-by-slice tracing approach. Repeatability is assessed by making repeated volume and diameter measurements on duplicated and randomized datasets. The proposed techniques were then utilized in a study of 21 patients from the Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation Trial (CABANA) pilot study who were scanned both before and approximately 3 months following ablation therapy. ResultsIn the high resolution CT scans the left atrial volume measurements show high accuracy with a mean absolute difference of 2.3 1.9cm3 between volumes computed with the proposed methodology and a manual slice-by-slice tracing approach. In the intra-rater repeatability study, the mean absolute difference in left atrial volume was 4.7 2.5cm3 and 4.4 3.4cm3 for the two raters. Intra-rater repeatability for pulmonary vein diameters ranged from 0.9 to 2.3mm. The inter-rater repeatability for left atrial volume was 5.8 5.1cm3 and inter-rater repeatability for pulmonary vein diameter measurements ranged from 1.4 to 2.3mm. In the patient study, significant (p |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1016/j.cmpb.2014.11.001 | Computer Methods and Programs in Biomedicine |
Keywords | Field | DocType |
Left atrium,Left atrial segmentation,Left atrial volume,Pulmonary vein diameter,Atrial fibrillation,Cardiac ablation therapy | Atrial fibrillation,Internal medicine,Cardiology,Catheter ablation,Left atrium,Computed tomography,Medicine,Absolute Change,Cardiac Ablation,Repeatability,Pulmonary vein | Journal |
Volume | Issue | ISSN |
118 | 2 | 0169-2607 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Maryam E. Rettmann | 1 | 382 | 46.20 |
| David R. Holmes III | 2 | 33 | 8.11 |
| Jerome F. Breen | 3 | 0 | 0.34 |
| Xin Ge | 4 | 0 | 0.34 |
| Ronald A Karwoski | 5 | 24 | 7.43 |
| Kristi H. Monahan | 6 | 0 | 0.34 |
| Tristram D. Bahnson | 7 | 0 | 0.34 |
| Douglas L. Packer | 8 | 4 | 6.03 |
| Richard A. Robb | 9 | 645 | 238.12 |