Name
Title | ||
|---|---|---|
Performance Evaluation of a Priori Information on Reconstruction of Fluorescence Molecular Tomography |
Abstract | ||
|---|---|---|
Fluorescence molecular tomography (FMT) plays an important role in in vivo small animal imaging. However, due to the diffusive nature of photon propagation in biological tissues, FMT suffers from a low spatial resolution, which limits its capability of resolving the distribution of fluorescent biomarkers. In this paper, we investigate the effect of functional and structural a priori information on the accuracy of FMT reconstruction by a hybrid FMT and X-ray computed tomography imaging system. The results from numerical simulation and phantom experiments suggest that the fluorescence targets embedded in heterogeneous medium can be localized when structural a priori information is utilized to constrain the reconstruction process. In addition, both the functional and structural a priori information are essential for the recovery of fluorophore concentration. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1109/ACCESS.2015.2402673 | IEEE Access |
Keywords | Field | DocType |
optical tomography,fmt reconstruction,photon propagation,computerised tomography,structural a priori information,biomedical optical imaging,image resolution,in vivo small animal imaging,spatial resolution,optical imaging,image reconstruction,reconstruction algorithms,fluorescence,functional a priori information,x-ray computed tomography imaging system,fluorescent biomarkers,fluorophore concentration,fluorescence molecular tomography,performance evaluation,biological tissues,phantoms,medical image processing,phantom,tomography,molecular imaging,in vivo,biomedical imaging | Biological system,Computer science,Medical imaging,Imaging phantom,A priori and a posteriori,Fluorophore,Artificial intelligence,Distributed computing,Iterative reconstruction,Computer vision,Molecular imaging,Tomography,Image resolution | Journal |
Volume | ISSN | Citations |
3 | 2169-3536 | 0 |
PageRank | References | Authors |
0.34 | 7 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Xin Liu | 1 | 8 | 2.42 |
| Zhuang-zhi Yan | 2 | 14 | 8.28 |
| Hongbing Lu | 3 | 325 | 37.37 |