Paper Info
Title
Axon-somatic back-propagation in detailed models of spinal alpha motoneurons.
Abstract
Antidromic action potentials following distal stimulation of motor axons occasionally fail to invade the soma of alpha motoneurons in spinal cord, due to their passing through regions of high non-uniformity. Morphologically detailed conductance-based models of cat spinal alpha motoneurons have been developed, with the aim to reproduce and clarify some aspects of the electrophysiological behavior of the antidromic axon-somatic spike propagation. Fourteen 3D morphologically detailed somata and dendrites of cat spinal alpha motoneurons have been imported from an open-access web-based database of neuronal morphologies, NeuroMorpho.org, and instantiated in neurocomputational models. An axon hillock, an axonal initial segment and a myelinated axon are added to each model. By sweeping the diameter of the axonal initial segment (AIS) and the axon hillock, as well as the maximal conductances of sodium channels at the AIS and at the soma, the developed models are able to show the relationships between different geometric and electrophysiological configurations and the voltage attenuation of the antidromically traveling wave. In particular, a greater than usually admitted sodium conductance at AIS is necessary and sufficient to overcome the dramatic voltage attenuation occurring during antidromic spike propagation both at the myelinated axon-AIS and at the AIS-soma transitions.
Year
DOI
Venue
2015
10.3389/fncom.2015.00015
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
Keywords
Field
DocType
spinal motoneuron,detailed model,back-propagation,axonal initial segment,sodium channel density
Alpha (ethology),Spinal cord,Axon hillock,Neuroscience,Soma,Computer science,Antidromic,Axon,Sodium channel,Electrophysiology
Journal
Volume
ISSN
Citations 
9
1662-5188
1
PageRank 
References 
Authors
0.37
4
3
Name
Order
Citations
PageRank
Pietro Balbi130.75
S Martinoia215820.68
Paolo Massobrio3213.62