Paper Info
Title
Differential effects of the ApoE4 genotype on brain structure and function.
Abstract
The apolipoprotein E ε4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE ε4 (ε4+) carriers and 25 non-carriers (ε4−), mean age 26.4±4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE ε4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the ε4 allele and might precede clinical or structural neurodegeneration.
Year
DOI
Venue
2014
10.1016/j.neuroimage.2013.11.042
NeuroImage
Keywords
Field
DocType
Apolipoprotein4,Memory,DTI,VBM,fMRI
Developmental psychology,Episodic memory,Neuroscience,Functional magnetic resonance imaging,Brain Structure and Function,Resting state fMRI,Cognitive psychology,Psychology,Brain activity and meditation,Voxel-based morphometry,Apolipoprotein E,Effects of sleep deprivation on cognitive performance
Journal
Volume
ISSN
Citations 
89
1053-8119
2
PageRank 
References 
Authors
0.40
6
13
Name
Order
Citations
PageRank
Silke Matura120.40
david prvulovic2508.03
Alina Jurcoane320.40
Daniel Hartmann420.40
Julia Miller520.40
Monika Scheibe620.40
Laurence O'Dwyer720.40
Viola Oertel-Knöchel8142.24
Christian Knöchel960.91
Britta Reinke1020.40
Tarik Karakaya1120.40
Fabian Fußer1220.40
Johannes Pantel1371.94