Name
Title | ||
|---|---|---|
The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain. |
Abstract | ||
|---|---|---|
T2*-weighted gradient-echo MRI images at high field (≥7T) have shown rich image contrast within and between brain regions. The source for these contrast variations has been primarily attributed to tissue magnetic susceptibility differences. In this study, the contribution of myelin to both T2* and frequency contrasts is investigated using a mouse model of demyelination based on a cuprizone diet. The demyelinated brains showed significantly increased T2* in white matter and a substantial reduction in gray-white matter frequency contrast, suggesting that myelin is a primary source for these contrasts. Comparison of in-vivo and in-vitro data showed that, although tissue T2* values were reduced by formalin fixation, gray-white matter frequency contrast was relatively unaffected and fixation had a negligible effect on cuprizone-induced changes in T2* and frequency contrasts. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2011.10.076 | NeuroImage |
Keywords | Field | DocType |
T2* decay,R2* relaxation,Phase image,Resonance frequency image,Demyelination,Cuprizone,Formalin fixation | Central nervous system,White matter,Psychology,Neuroimaging,Cerebral cortex,Corpus callosum,Fixation (histology),Pathology,Myelin,Magnetic resonance imaging | Journal |
Volume | Issue | ISSN |
59 | 4 | 1053-8119 |
Citations | PageRank | References |
39 | 1.92 | 16 |
Authors | ||
10 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jongho Lee | 1 | 74 | 6.15 |
| Karin Shmueli | 2 | 165 | 12.88 |
| Byeong-Teck Kang | 3 | 39 | 1.92 |
| Bing Yao | 4 | 47 | 2.75 |
| Masaki Fukunaga | 5 | 319 | 27.13 |
| Peter van Gelderen | 6 | 403 | 35.74 |
| Sara Palumbo | 7 | 39 | 1.92 |
| Francesca Bosetti | 8 | 40 | 2.42 |
| Afonso C. Silva | 9 | 220 | 18.38 |
| Jeff H. Duyn | 10 | 839 | 48.39 |