Name
Title | ||
|---|---|---|
Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects. |
Abstract | ||
|---|---|---|
Variation in the CACNA1C gene has consistently been associated with psychosis in genome wide association studies. We have previously shown in a sample of n=110 healthy subjects that carriers of the CACNA1C rs1006737 risk variant exhibit hippocampal and perigenual anterior cingulate dysfunction (pgACC) during episodic memory recall. Here, we aimed to replicate our results, by testing for the effects of the rs1006737 risk variant in a new large cohort of healthy controls. We furthermore sought to refine these results by identifying the impact of a CACNA1C specific, gene-wide risk score in the absence of clinical pathology. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1016/j.neuroimage.2014.03.007 | NeuroImage |
Keywords | Field | DocType |
fMRI,Imaging genetics,CACNA1C,Hippocampus,Perigenual anterior cingulate,Dorsolateral prefrontal cortex | Episodic memory,Developmental psychology,Neuroscience,Bipolar disorder,Functional magnetic resonance imaging,Imaging genetics,Psychosis,Dorsolateral prefrontal cortex,Psychology,Genome-wide association study,Psychiatry,Schizophrenia | Journal |
Volume | ISSN | Citations |
94 | 1053-8119 | 0 |
PageRank | References | Authors |
0.34 | 2 | 22 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Susanne Erk | 1 | 125 | 9.64 |
| Andreas Meyer-Lindenberg | 2 | 253 | 18.54 |
| D E J Linden | 3 | 289 | 32.19 |
| Thomas Lancaster | 4 | 1 | 1.06 |
| Sebastian Mohnke | 5 | 60 | 2.42 |
| Oliver Grimm | 6 | 100 | 5.22 |
| Franziska Degenhardt | 7 | 0 | 0.68 |
| Peter Holmans | 8 | 37 | 0.94 |
| Andrew Pocklington | 9 | 0 | 0.34 |
| Phöbe Schmierer | 10 | 0 | 0.34 |
| Leila Haddad | 11 | 110 | 5.45 |
| Thomas W Mühleisen | 12 | 5 | 1.14 |
| Manuel Mattheisen | 13 | 1 | 1.23 |
| Stephanie H Witt | 14 | 12 | 2.47 |
| Nina Seiferth | 15 | 60 | 2.42 |
| Heike Tost | 16 | 44 | 3.97 |
| Björn Schott | 17 | 4 | 1.63 |
| Sven Cichon | 18 | 12 | 1.64 |
| Markus M Nöthen | 19 | 18 | 4.07 |
| Marcella Rietschel | 20 | 27 | 5.81 |
| Andreas Heinz | 21 | 60 | 2.42 |
| Henrik Walter | 22 | 198 | 25.70 |