Paper Info
Title
Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties.
Abstract
The human network of Protein-Protein Interactions (PPIs) (interactome) provides information on biological systems that can be used to aid prediction of protein function and disease association. As some classes of protein may be the focus of much study, data sets may contain bias, which may affect the results of network analyses. Implicated cancer proteins and proteins including significant known mediators of cardiovascular disease (cvd) display a tendency to play a central role in a previously constructed interactome. However, removing possible bias in the interactome by only considering interactions obtained from non-targeted approaches affects the significance of the findings.
Year
DOI
Venue
2014
10.1504/IJDMB.2014.062150
IJDMB
Keywords
DocType
Volume
PPI, protein-protein interaction, protein interaction network, network analysis, cardiovascular disease, cancer, disease network
Journal
9
Issue
ISSN
Citations 
4
1748-5673
0
PageRank 
References 
Authors
0.34
9
4
Name
Order
Citations
PageRank
Richard J B Dobson1442.79
Patricia B. Munroe2443.12
Mark J. Caulfield3462.95
Mansoor A. S. Saqi410713.49