Name
Abstract | ||
|---|---|---|
In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-kappa B) signalling pathway. NF-kappa B is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-kappa B signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-kappa B into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-kappa B control. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.3390/computation2040131 | COMPUTATION |
Keywords | Field | DocType |
NF-kappa B, computational biology, agent-based modelling, mathematical modelling, systems biology, signal transduction | Transcription (biology),Biology,Cytoplasm,Systems biology,Cell biology,Cell membrane,Hedgehog signaling pathway,Signal transduction,Immune system,Transcription factor | Journal |
Volume | Issue | ISSN |
2 | 4 | 2079-3197 |
Citations | PageRank | References |
2 | 0.39 | 10 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Richard A. Williams | 1 | 7 | 1.81 |
| Jon Timmis | 2 | 1237 | 120.32 |
| Eva E Qwarnstrom | 3 | 3 | 1.41 |