Title
Census 2: isobaric labeling data analysis.
Abstract
We introduce Census 2, an update of a mass spectrometry data analysis tool for peptide/protein quantification. New features for analysis of isobaric labeling, such as Tandem Mass Tag (TMT) or Isobaric Tags for Relative and Absolute Quantification (iTRAQ), have been added in this version, including a reporter ion impurity correction, a reporter ion intensity threshold filter and an option for weighted normalization to correct mixing errors. TMT/iTRAQ analysis can be performed on experiments using HCD (High Energy Collision Dissociation) only, CID (Collision Induced Dissociation)/HCD (High Energy Collision Dissociation) dual scans or HCD triple-stage mass spectrometry data. To improve measurement accuracy, we implemented weighted normalization, multiple tandem spectral approach, impurity correction and dynamic intensity threshold features.
Year
DOI
Venue
2014
10.1093/bioinformatics/btu151
BIOINFORMATICS
Field
DocType
Volume
Collision-induced dissociation,Mass spectrometry data format,Isobaric labeling,Normalization (statistics),Computer science,Mass spectrometry,Bioinformatics,Tandem mass tag,Accuracy and precision,Isobaric process
Journal
30
Issue
ISSN
Citations 
15
1367-4803
0
PageRank 
References 
Authors
0.34
0
12