Title
A Pathway-Based Mean-Field Model for E. coli Chemotaxis: Mathematical Derivation and Its Hyperbolic and Parabolic Limits.
Abstract
A pathway-based mean-field theory (PBMFT) that incorporated the most recent quantitatively measured signaling pathway was recently proposed for the E. coli chemotaxis in [G. Si, T. Wu, Q. Quyang, and Y. Tu, Phys. Rev. Lett., 109 (2012), 048101]. In this paper, we formally derive a new kinetic system of PBMFT under the assumption that the methylation level is locally concentrated, whose turning operator takes into account the dynamical intracellular pathway and hence is more physically relevant. We recover the PBMFT proposed by Si et al. as the hyperbolic limit and connect to the Keller-Segel equation as the parabolic limit of this new model. We also present the numerical evidence to show the quantitative agreement of the kinetic system with the individual based E. coli chemotaxis simulator.
Year
DOI
Venue
2014
10.1137/130944199
MULTISCALE MODELING & SIMULATION
Keywords
Field
DocType
pathway-based mean-field model,E. coli chemotaxis,hyperbolic limit,parabolic limit,Keller-Segel model
Chemotaxis,Mathematical optimization,Mathematical analysis,Mean field theory,Operator (computer programming),Mathematics,Parabola,Kinetic energy
Journal
Volume
Issue
ISSN
12
2
1540-3459
Citations 
PageRank 
References 
1
0.48
7
Authors
3
Name
Order
Citations
PageRank
Guangwei Si110.48
Min Tang242.94
Xu Yang3459.17